Objective To investigate the application effect of continuous nursing based on informatization platform in acne scar patients treated with carbon dioxide fractional laser. Methods From January to December 2023, 94 patients with facial acne scar admitted to the Plastic and Cosmetic Department of the First Affiliated Hospital of Guangdong Pharmaceutical University were selected as the research subjects, and they were randomly divided into control group and observation group, with 47 patients in each group. All patients were treated with carbon dioxide fractional laser, and the control group was given conventional nursing after operation, while the observation group was given continuous nursing based on informationization platform. The pain level, psychological state, self-care ability, nursing satisfaction and adverse reactions were compared between the two groups. Results The VAS score in the observation group during nursing and at 30 min and 3 h after nursing was lower than that in the control group (P <0.05). After nursing, the scores of SAS and SDS in the observation group were lower than those in the control group (P <0.05). The scores of self-care ability in the observation group were higher than those in the control group (P <0.05). The nursing satisfaction in the observation group (97.87%) was higher than that in the control group (82.98%) (P <0.05). The incidence of adverse reactions in the observation group (6.38%) was lower than that in the control group (14.89%) (P <0.05). Conclusion The application effect of continuous nursing based on informatization platform in acne scar patients treated with carbon dioxide fractional laser is accurate, which can effectively alleviate the pain and discomfort related to the treatment and adverse psychological state of the patients, improve their self-care ability. It is helpful to improve the nursing satisfaction and reduce the incidence of adverse reactions.