Objective To analyze the effect of oral implant restoration on periodontal indexes and gingival sulcus inflammatory indexes in patients with dentition defect. Methods A total of 60 patients with dentition defect admitted to the Department of Stomatology, Xi'an Fengcheng Hospital from August 2022 to August 2024 were selected as the research subjects, and they were divided into the control group and the observation group according to the random number table method, with 30 patients in each group. The control group received conventional restoration, and the observation group received oral implant restoration. The periodontal indexes, gingival sulcus inflammatory indexes, restoration effect, adverse events and satisfaction were compared between the two groups. Results After treatment, the GI, SBI and PLI in the observation group were all lower than those in the control group, and the differences were statistically significant (P <0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the observation group were all lower than those in the control group, and the differences were statistically significant (P <0.05). The total effective rate of restoration in the observation group was 100.00%, which was higher than 73.33% in the control group, and the difference was statistically significant (P <0.05). The incidence of adverse events in the observation group was 0, which was lower than 20.00% in the control group, and the difference was statistically significant (P <0.05). The satisfaction rate in the observation group was 100.00%, which was higher than 73.33% in the control group, and the difference was statistically significant (P <0.05). Conclusion The application of oral implant restoration in the treatment of dentition defect can effectively improve the periodontal indexes of patients, alleviate the inflammatory reaction of the gingival sulcus, reduce the incidence of adverse events, and improve the restoration effect and patient satisfaction.