Objective To analyze the effect of glass fiber post on gingival crevicular fluid inflammatory factor levels and masticatory function in patients with anterior tooth defect. Methods A total of 80 patients with anterior tooth defect admitted to Luodian County Traditional Chinese Medicine Hospital from January to December 2023 were selected. According to the random number table method, they were divided into the control group and the observation group, with 40 patients in each group. The control group was treated with metal post restoration, and the observation group was treated with glass fiber post restoration. The restoration success rate, gingival crevicular fluid inflammatory factor levels [interleukin-17 (IL-17), interleukin-6 (IL-6)] and masticatory function were compared between the two groups. Results The restoration success rate in the observation group was 97.50%, which was higher than 80.00% in the control group (P <0.05). After treatment, the levels of IL-17 and IL-6 in the observation group were lower than those in the control group (P <0.05). After treatment, the occlusal force and masticatory efficiency in the observation group were higher than those in the control group (P <0.05). Conclusion For patients with anterior tooth defect, the application of glass fiber post in aesthetic restoration can not only effectively improve the restoration success rate, but also reduce the oral inflammatory response and restore the masticatory function.