Objective To explore the effect of multi-dimensional nursing based on empowerment theory on wound healing and satisfaction in patients undergoing mid-facial defect restoration. Methods A total of 76 patients with mid-facial defect admitted to our hospital from June 2022 to March 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 38 patients in each group. The control group was given conventional nursing, and the observation group was given multi-dimensional nursing based on empowerment theory. The clinical indicators, wound healing quality, flap repair aesthetics, complications and nursing satisfaction were compared between the two groups. Results The wound healing time and hospitalization time in the observation group were shorter than those in the control group (P <0.05). The excellent and good rate of wound healing in the observation group was 92.11%, which was higher than 73.68% in the control group (P <0.05). The aesthetics scores of the recipient area color, texture and morphological contour in the observation group were all higher than those in the control group (P <0.05). The incidence of complications in the observation group was 7.89%, which was lower than 28.95% in the control group (P <0.05). The nursing satisfaction rate in the observation group was 94.74%, which was higher than 78.95% in the control group (P <0.05). Conclusion The multi-dimensional nursing mode based on empowerment theory can more effectively promote the wound healing and rehabilitation of patients undergoing mid-facial defect restoration, reduce the risk of complications, improve the aesthetics of flap repair and patient satisfaction.