Objective To evaluate the efficacy and safety of subcision technology combined with ultra-pulsed carbon dioxide fractional laser in the treatment of acne depressed scar. Methods Databases such as CNKI, Wanfang Database, Chinese Biomedical Literature Database, Chinese Medical Association, PubMed, Medline, Embase and the Cochrane Library were searched to collect published RCTs of subcision technology combined with ultra-pulsed carbon dioxide fractional laser compared with ultra-pulsed carbon dioxide fractional laser alone for the treatment of acne depressed scar. The search date was not limited, and three collaborators independently performed the analysis and screening. RevMan 5.3 was used for data analysis and publication bias analysis of the included literatures. Results A total of 14 literatures were included. The results of meta-analysis showed that the total effective rate of the experimental group was better than that of the control group, the ECCA score of the experimental group after treatment was lower than that before treatment and lower than that of the control group after treatment (P <0.05). There was no significant difference in the incidence of adverse reactions between the experimental group and the control group (P ＞0.05). Conclusion Compared with the treatment of ultra-pulsed carbon dioxide fractional laser alone, subcision technology combined with ultra-pulsed carbon dioxide fractional laser is more effective in the treatment of acne depressed scars, which can improve the scar condition, and the incidence of adverse reactions will not increase significantly. It is worthy of clinical application.