Objective To develop a new anti-acne raw material, weak chelation recombinant collagen zinc, and analyze the long-term release and anti-inflammatory effects of zinc ions through the weak chelation technology. Methods The weak chelation recombinant collagen zinc raw material was prepared and characterized using specific pH and mass ratios. The physicochemical properties of the raw materials were comprehensively evaluated by various analytical techniques such as inductive coupling, scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS). Results The chelation rate of collagen zinc increased first and then decreased, reaching the highest at a ratio of 10/8. The characteristic absorption peak of its chelate was red-shifted, with increased intensity at 1600-1400 cm-1. In the simulation experiment of zinc ion release in vitro , the whole release process of 1 mg/ml of weak chelation recombinant collagen zinc (10/8) was more stable. Under the same level of zinc ion concentration, zinc gluconate was completely released within 1 h, while the zinc ion release process of weak chelation recombinant collagen zinc (10/8) could last for 4 h. When the concentration of weak chelation recombinant collagen zinc was 10%, the inhibition rate of 5α-reductase was (46.70±1.30)%, which was higher than the average inhibition rate of the pure collagen control group and the positive control, and increased with the increase of concentration. At the concentration of 1%, it showed the highest antibacterial rate at all time points. With the extension of time, the antibacterial rate increased significantly, reaching 84.96% at 8 h. Conclusion The weak chelation recombinant collagen zinc raw material provides a new and effective option for acne treatment, with potential applications in the cosmetics industry.