Objective To analyze the effect of micro-titanium screw implant anchorage on orthodontic treatment effect and oral indexes in patients with maxillary protrusion. Methods A total of 86 patients with maxillary protrusion admitted to our hospital from January 2022 to January 2024 were selected as the research subjects. According to different treatment methods, they were divided into the control group (n =43) and the observation group (n =43). The control group was given extraoral arch anchorage, and the observation group was given micro-titanium screw implant anchorage. The oral indexes, PAR indexes and adverse reactions were compared between the two groups. Results After treatment, the upper lip protrusion, lower lip protrusion and upper central incisor inclination in the observation group were lower than those in the control group (P <0.05). After treatment, the scores of teeth arrangement, overjet, overbite, posterior occlusion and midline in the observation group were lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was 6.98%, which was lower than 27.91% in the control group (P <0.05). Conclusion Micro-titanium screw implant anchorage helps to improve the upper and lower lip protrusion and upper central incisor inclination of patients undergoing orthodontic treatment for maxillary protrusion, reduce the PAR indexes, and decrease the incidence of adverse reactions, with high application value.