Objective To analyze the clinical effective mechanism of picosecond laser combined with photorejuvenation intervention for patients with facial pigmentation after burns. Methods from December 2022 to December 2024, 80 patients with facial pigmentation after burn in Juye Fenghuang community health service center were enrolled. Combined with different treatment schemes, the patients were divided into reference group (picosecond laser treatment, n=40) and Analysis Group (photorejuvenation+picosecond laser treatment, n=40). The pigmentation, complication rate and treatment satisfaction were compared after 3 months of intervention. Results at 3 months after the intervention, the pigmentation of the analysis group (pigment degree symptoms, pigment number symptoms, skin lesion size score and emotional impact score) were lower than those of the reference group and the group before the intervention, and the parameter difference was established (P<0.05). The incidence of complications in the analysis group (2.50%) was lower than that in the reference group (15.00%), and the parameter difference was established (P<0.05). After the intervention, the nursing satisfaction level of the analysis group was 97.50%, which was higher than 82.50% of the reference group, and the parameter difference was established (P<0.05). Conclusion: in the intervention of facial burn pigmentation, the introduction of photorejuvenation+picosecond laser treatment is conducive to the improvement of pigmentation, which is not only safe, but also can improve the level of nursing satisfaction of patients, and can be popularized.