Objective To explore the effect of adhesive denture in the treatment of completely edentulous on denture restoration effect. Methods A total of 60 completely edentulous patients admitted to our hospital from January 2023 to June 2024 were selected as the research subjects. According to different treatment plans, they were divided into the control group and the observation group, with 30 patients in each group. The control group received traditional denture treatment, and the observation group received adhesive denture treatment. The clinical efficacy, denture restoration effect, quality of life and treatment satisfaction were compared between the two groups. Results The total effective rate of treatment in the observation group (96.67%) was higher than that in the control group (73.33%) (P<0.05). The scores of denture stability, language ability, masticatory function and wearing comfort in the observation group were higher than those in the control group (P<0.05). After treatment, the SF-36 scores in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group (P<0.05). The treatment satisfaction in the observation group was higher than that in the control group (P<0.05). Conclusion The application of adhesive denture in the treatment of completely edentulous can achieve a more ideal treatment effect. It can maintain the denture stability, improve the language ability of patients, promote the recovery of their masticatory function, meet the wearing comfort requirements at the same time, and help to improve their quality of life and treatment satisfaction.