Objective To analyze the effect of nursing intervention guided by KANO model on ocular comfort and visual function in patients undergoing ophthalmic surgery. Methods A total of 100 patients who underwent ophthalmic surgery in our hospital from January to October 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 50 patients in each group. The control group received routine nursing, and the observation group received nursing intervention guided by KANO model. The ocular comfort, visual function, compliance behavior, visual satisfaction and quality of life were compared between the two groups. Results After nursing, the scores of various items of ocular comfort in the observation group were all lower than those in the control group (P <0.05). There were no significant differences in uncorrected visual acuity (UCVA), corneal curvature and corneal astigmatism degree (CAD) between the two groups (P >0.05). The proportion of various items of compliance behavior in the observation group were all higher than those in the control group (P <0.05). The visual satisfaction rate in the observation group (98.00%) was higher than that in the control group (70.00%) (P <0.05). The scores of various items of quality of life in the observation group were all higher than those in the control group (P <0.05). Conclusion The application of nursing intervention guided by KANO model in patients undergoing ophthalmic surgery can improve the postoperative ocular comfort, effectively improve the visual function, and enhance the compliance behavior. Meanwhile, patients have a high visual satisfaction rate and a high prognosis quality of life, which is worthy of clinical application.