Objective To explore the effect of sequential pressure rehabilitation nursing intervention on the scar and skin function recovery of patients with large-area hypertrophic scar. Methods A total of 84 patients with large-area hypertrophic scar admitted to the First People's Hospital of Kunshan from January 2022 to June 2024 were selected as the research subjects. According to the random number table method, they were divided into the reference group and the study group, with 42 patients in each group. The reference group was given conventional nursing intervention, and the study group was given sequential pressure rehabilitation nursing intervention on the basis of the reference group. The scar conditions, skin function recovery, negative emotions, nursing satisfaction, complications and quality of life were compared between the two groups. Results The scar thickness and scar area in the study group were both smaller than those in the reference group (P <0.05). The transepidermal water loss in the study group was lower than that in the reference group, and the stratum corneum hydration was higher than that in the reference group (P <0.05). After nursing, the scores of SAS and SDS in the study group were both lower than those in the reference group (P <0.05). The nursing satisfaction rate in the study group (97.62%) was higher than that in the reference group (80.95%) (P <0.05). The incidence of complications in the study group (2.38%) was lower than that in the reference group (19.05%) (P <0.05). After nursing, the quality of life score in the study group was higher than that in the reference group (P <0.05). Conclusion The application of sequential pressure rehabilitation nursing intervention in patients with large-area hypertrophic scar has a good effect, which can effectively improve the recovery of scar and skin function, help to reduce negative emotions, and reduce the incidence of complications. Moreover, it has a positive significance for improving the nursing satisfaction and quality of life of patients.