Objective To explore the application effect of the doctor-nurse-patient collaborative outpatient follow-up guidance model in patients undergoing oral implant sinus lift surgery. Methods A total of 80 patients who underwent oral implant sinus lift surgery in our hospital from May 2022 to May 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 40 patients in each group. The control group received conventional follow-up guidance, and the observation group received the doctor-nurse-patient collaborative outpatient follow-up guidance model on the basis of the control group. The oral health knowledge, compliance behavior, complications, implant stability and satisfaction were compared between the two groups. Results After intervention, the scores of each dimension of the oral health knowledge in the two groups were higher than those before intervention, and those in the observation group were higher than those in the control group (P <0.05). The proportion of medication adherence, timely follow-up visits, oral hygiene maintenance and good eating habits in the observation group was higher than that in the control group (P <0.05). The incidence of adverse reactions in the observation group (5.00%) was lower than that in the control group (25.00%) (P <0.05). There was no significant difference in implant stability between the two groups at 1, 3, and 6 months after surgery (P >0.05). The satisfaction score in the observation group was higher than that in the control group (P <0.05). Conclusion The doctor-nurse-patient collaborative outpatient follow-up guidance model can effectively improve the oral health knowledge of patients undergoing oral implant sinus lift surgery and enhance their compliance behavior. It is beneficial to improving implant stability and reducing the incidence of complications, with high patient satisfaction. It is worthy of clinical application.