Objective To analyze the clinical effect of micro-implants in patients undergoing orthodontics treatment for teeth malocclusion. Methods A total of 73 patients with teeth malocclusion admitted to the Department of Stomatology, Zhuozhou Pediatric Outpatient Department, Beijing Bei Er Dou Dian Children's Hospital Co., Ltd. from January 2022 to December 2023 were selected. According to different treatment plans, they were divided into the control group (n =35) and the observation group (n =38). The control group received conventional orthodontics treatment, and the observation group received micro-implants treatment. The orthodontic effect, dental aesthetic effect, cephalometric indexes [Sella-Nasion-A point angle (SNA), A point-Nasion-B point angle (ANB), Sella-Nasion-B point angle (SNB)] and gingival crevicular fluid inflammatory factors were compared between the two groups. Results There was no significant difference in the total effective rate between the two groups (P >0.05). After 6 and 12 months of orthodontics treatment, the dental aesthetic effect score in the observation group was higher than that in the control group (P <0.05). After 12 months of orthodontics treatment, the SNA and ANB in the observation group were higher than those in the control group (P <0.05), but there was no significant difference in SNB between the two groups (P >0.05). After orthodontics treatment, the levels of IL-6 and IL-8 in the two groups were higher than those before orthodontics treatment, but those in the observation group were lower than those in the control group (P <0.05). Conclusion Compared with conventional orthodontics treatment, micro-implant anchorage can achieve a comparable orthodontic effect, and it can improve the dental aesthetic effect, promote the growth of maxilla, and reduce the levels of inflammatory factors in gingival crevicular fluid.