Objective To analyze the effect of orthodontics combined with periodontal treatment on patients with periodontitis and anterior tooth displacement. Methods A total of 70 patients with periodontitis and anterior tooth displacement admitted to Hangzhou Stomatology Hospital Group Chengxi Stomatology Hospital Co., Ltd. from January 2022 to June 2023 were selected as the research subjects. According to the random number table method, they were divided into the control group and the study group, with 35 patients in each group. The control group received conventional periodontal treatment, and the study group received conventional periodontal treatment combined with orthodontics treatment. The clinical efficacy, periodontal indexes[Sulcus Bleeding Index (SBI), Gingival Index (GI), Plaque Index (PLI), Probing Depth (PD)], dental aesthetics (coverage distance of anterior teeth, gingival papilla height, tooth diastema) and complications (periodontal bleeding, infection, pain) were compared between the two groups. Results The total effective rate of treatment in the study group was 94.29%, which was higher than 74.29% in the control group (P <0.05). After treatment, the SBI, GI, PLI and PD in the study group were lower than those in the control group (P <0.05). After treatment, the coverage distance of anterior teeth and the tooth diastema in the study group were lower than those in the control group, while the gingival papilla height in the study group was higher than that in the control group (P <0.05). The incidence of complications in the study group was lower than that in the control group (P <0.05). Conclusion Orthodontics combined with periodontal treatment has a definite clinical effect on patients with periodontitis and anterior tooth displacement. It can improve the levels of periodontal indexes, enhance the dental aesthetics, and has high safety, which is worthy of clinical application.