Objective To observe the effect of Qufu Shengji ointment in the treatment of patients undergoing stamp skin grafting plastic surgery. Methods From January 2020 to June 2024, 60 patients who underwent stamp skin grafting plastic surgery and were admitted to the Second Department of Orthopedics, Huanghua Municipal People's Hospital from January 2020 to June 2024 were selected. According to the random number table method, they were divided into the control group and the study group, with 30 patients in each group. The control group was treated with routine dressing change, and the study group was treated with Qufu Shengji ointment. The recovery situation after skin grafting, wound aesthetics, complications and patient satisfaction were compared between the two groups. Results The skin graft survival time, new epithelial appearance time, wound healing time and hospitalization time in the study group were shorter than those in the control group (P <0.05). After treatment, the scores of each dimension of OSAS in the study group were lower than those in the control group (P <0.05). The incidence of complications in the study group was 6.67%, which was lower than 26.67% in the control group (P <0.05). The total satisfaction rate of patients in the study group was 100.00%, which was higher than 80.00% in the control group (P <0.05). Conclusion The application of Qufu Shengji ointment in the treatment of patients undergoing stamp skin grafting plastic surgery can accelerate their postoperative recovery, improve the wound aesthetics, and reduce the incidence of complications, with higher patient satisfaction.