Objective: This study aimed to compare the efficacy, safety, and patient satisfaction of intense pulsed light (IPL) devices with different wavelength ranges (510–1200 nm vs. 600–1200 nm) for hair removal across different body sites.Methods: A total of 132 patients seeking hair removal treatment were enrolled from January 2024 to October 2024 and randomly divided into an observation group (n=66) and a control group (n=66) using a random number table. The control group received IPL treatment with a wavelength range of 510–1200 nm, while the observation group was treated with a 600–1200 nm IPL device. Treatment efficacy, hair density reduction rate, adverse reactions, and patient satisfaction were compared between the two groups across different body areas.Results: The overall efficacy rates between the two groups showed no significant difference. However, the observation group exhibited significantly higher hair density reduction rates in the lip (92.40%), lower leg (94.92%), and arm (87.24%) compared to the control group (84.42%, 85.29%, and 82.25%, respectively; P<0.05). The incidence of adverse reactions in the observation group (3.03%) was significantly lower than that in the control group (12.12%; P<0.05). Patient satisfaction was significantly higher in the observation group (98.48%) than in the control group (89.40%; P<0.05).Conclusion: The 600–1200 nm wavelength range demonstrates superior efficacy for lip, lower leg and arm hair removal, along with higher patient satisfaction. Lower cutoff wavelengths may increase the risk of epidermal adverse reactions. Clinicians should select IPL devices with appropriate wavelength ranges based on the treatment site.