Objective To explore the effect of M22 photorejuvenation technology in the treatment of facial telangiectasia. Methods A total of 100 patients with facial telangiectasia admitted to Wuzhong District Chengnan Street Community Health Service Center from November 2023 to June 2024 were selected. According to the random number table method, they were divided into the control group and the observation group, with 50 patients in each group. The control group was treated with 595 nm pulsed dye laser, and the observation group was treated with M22 photorejuvenation technology. The treatment effect, aesthetic effect of facial capillaries, capillary morphology and skin structure were compared between the two groups. Results The total effective rate of treatment in the observation group was 94.00%, which was higher than 78.00% in the control group (P <0.05). After treatment, the aesthetic effect score of facial capillaries and the facial capillary morphology score in the observation group were lower than those in the control group (P <0.05). After treatment, the dermal papilla density in the observation group was lower than that in the control group, and the capillary diameter and stratum corneum thickness in the observation group were higher than those in the control group (P <0.05). Conclusion M22 photorejuvenation technology has a good treatment effect on patients with facial telangiectasia. It can induce changes in the skin structure, reduce capillary diameter, and enhance facial aesthetics and capillary morphology, which is worthy of clinical application.