Objective To study the effect of monopolar radiofrequency technology combined with collagen periocular injection in periocular anti-aging. Methods A total of 98 patients who underwent periocular anti-aging treatment in Xi'an Yestar Medical Beauty Hospital from June 2022 to June 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group (n =49) and the experimental group (n =49). The control group was treated with single monopolar radiofrequency technology, and the experimental group was combined with collagen periocular injection on the basis of the control group. The changes of periocular wrinkle grading, skin aging, electromyographic index of orbicularis oculi muscle, periocular skin moisture content and periocular anti-aging treatment satisfaction were compared between the two groups. Results After 2 months of treatment, the proportion of grade 0 and grade 1 periocular wrinkles in the experimental group was higher than that in the control group (P <0.05 ), and the proportion of grade 2 and grade 3 periocular wrinkles was lower than that in the control group (P <0.05), while there was no significant difference in the proportion of grade 4 periocular wrinkles between the two groups (P >0.05). After 2 months of treatment, the VISIA score of periocular skin aging in the experimental group was lower than that in the control group (P <0.05). After 2 months of treatment, the electromyographic index of orbicularis oculi muscle in the experimental group was lower than that in the control group (P <0.05). After 2 months of treatment, the periocular skin conductivity and periocular stratum corneum hydration in the experimental group were higher than those in the control group (P <0.05). The total satisfaction rate of periocular anti-aging treatment in the experimental group was 93.88%, which was higher than 77.55% in the control group (P <0.05). Conclusion In the treatment of periocular anti-aging, the combination of collagen periocular injection and monopolar radiofrequency technology has a better periocular anti-aging effect. It is beneficial to improving the grading of periocular wrinkles, delaying skin aging and muscle atrophy, and enhancing the periocular skin water content and the satisfaction with periocular anti-aging treatment.