Objective: To explore the application effect of Digital Smile Design (DSD) in the invisible correction of mild to moderate malocclusion in children. Methods: A total of 70 children with mild to moderate malocclusion who visited our hospital from January 2022 to January 2025 were selected and randomly divided into an observation group (treated with DSD combined with invisible orthodontics) and a control group (treated with invisible orthodontics alone), with 35 cases in each group. The tooth alignment, occlusal relationship, smile aesthetic indicators and patient satisfaction of the two groups before and after treatment were compared.Results: Before treatment, there was no difference in the degree of dentition crowding and the width of tooth space between the two groups (P>0.05). After treatment, it was found that the change of the observation group was better, and the degree of dentition crowding and the width of tooth space were smaller (P<0.05); Before treatment, the difference of ANB angle between the two groups was very small (P>0.05). After treatment, the reduction of ANB angle in the observation group was greater than that in the control group (P<0.05); Before treatment, there was no significant difference in the overbite coverage of the upper and lower anterior teeth between the two groups (P>0.05). The change after treatment was more significant in the observation group, which was lower than that in the control group (P<0.05); After treatment, the observation group was better than the control group in smile arc coordination, upper anterior teeth exposure and quarrel position (P<0.05); The observation group was more satisfied with the treatment, and the satisfaction reached 94.29%, while the control group was only 77.14%, with significant difference between the two groups (P<0.05). Conclusion: The application of DSD in the invisible correction of mild to moderate malocclusion in children can significantly improve the correction effect, enhance the aesthetics of smiling, and increase patient satisfaction, which has important clinical application value.