Objective To explore the effect of orthodontics combined with oral restoration treatment on language function, masticatory function and quality of life in patients with congenital missing teeth. Methods A total of 68 patients with congenital missing teeth who received treatment in the Department of Stomatology, the People's Hospital of Dehong from April 2019 to April 2020 were selected as the research subjects. According to the random number table method, they were divided into the control group and the combined group, with 34 patients in each group. The control group received oral restoration treatment, and the combined group received orthodontics combined with oral restoration treatment. The clinical effect, oral function and its recovery time, treatment satisfaction and quality of life were compared between the two groups. Results The total effective rate of treatment in the combined group (91.18%) was higher than that in the control group (64.71%) (P <0.05). The scores of language function and masticatory function in the combined group were higher than those in the control group (P <0.05). The recovery time of language function and masticatory function in the combined group was shorter than that in the control group (P <0.05). The scores of physical, psychological, social and learning aspects in the combined group were higher than those in the control group (P <0.05). The treatment satisfaction rate in the combined group was higher than that in the control group (P <0.05). Conclusion The clinical effect of orthodontics combined with oral restoration treatment in the treatment of congenital missing teeth is better, which can effectively improve the language and masticatory functions of patients, shorten the functional recovery time, improve the treatment satisfaction and quality of life. It is worthy of clinical application.