Abstract:Objective To investigate the effect of catgut implantation at acupoint combined with tranexamic acid on the color and area of skin lesions in patients with melasma. Methods A total of 74 patients with melasma admitted to our hospital from April 2022 to June 2023 were selected as the research subjects, and they were divided into the control group and the research group by the random number table method, with 37 patients in each group. The control group was treated with tranexamic acid, and the research group was treated with catgut implantation at acupoint combined with tranexamic acid. The clinical efficacy, skin lesion improvement, skin barrier function and TCM syndrome score improvement were compared between the two groups. Results The total effective rate of treatment in the research group was 97.30%, which was higher than 81.08% in the control group (P<0.05). After treatment, the scores of skin lesion area and color in the research group were lower than those in the control group (P<0.05). After treatment, the transepidermal water loss value, sebum content and stratum corneum hydration in the research group were better than those in the control group (P<0.05). After treatment, the TCM syndrome score in the research group was (6.37±1.43)scores, which was lower than (9.88±1.84)scores in the control group (P <0.05). Conclusion Catgut implantation at acupoint combined with tranexamic acid has a good clinical effect in the treatment of patients with melasma, which can effectively improve the facial skin lesions and skin barrier function, and reduce the TCM syndrome score. It is worthy of clinical application.