Objective To investigate the expression profile and functional roles of circular RNA (circRNA) in photoaged human skin. Methods Facial photoaged skin tissues (experimental group) and hip/abdomen skin tissues (control group) were collected. circRNA microarray analysis was performed to compare circRNA expression profiles between photoaged and non-photoaged skin groups, and qPCR was used to verify the microarray results. Results A total of 202 differentially expressed circRNAs were identified. GO/KEGG pathway analysis showed that the parental genes of differentially expressed circRNAs were enriched in pathways related to extracellular matrix and collagen metabolism. qPCR confirmed that hsa_circRNA_102207 was significantly downregulated in the experimental group (P≤0.001). Conclusion Abnormally expressed circRNAs in photoaged skin may participate in the pathological process by regulating extracellular matrix remodeling, collagen organization, and key photoaging pathways.