Objective To explore the efficacy and safety of 595 nm pulsed dye laser in improving skin ecchymosis. Methods A total of 40 patients with skin ecchymosis admitted to Chongqing Xiaoke BeauCare Clinic were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 20 patients in each group. The control group was treated with mucopolysaccharide polysulfate cream, and the observation group was treated with 595 nm pulsed dye laser. The clinical efficacy, ecchymosis severity and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group (100.00%) was higher than that in the control group (65.00%) (P <0.05). The scores of ecchymosis in the observation group immediately after treatment, 24 hours after treatment, and 3 and 7 days after treatment were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion For patients with skin ecchymosis, treatment with 595 nm pulsed dye laser can improve the clinical efficacy and the severity of ecchymosis without increasing the incidence of adverse reactions.