Objective: To investigate the effects of periodontal basic treatment combined with orthodontic treatment on periodontal pocket depth (PD) and bleeding index (BI) in patients with periodontitis-induced anterior tooth displacement. Methods: Ninety patients with periodontitis-induced anterior tooth displacement from January 2021 to December 2023 were randomly divided into a control group (45 cases, basic periodontal treatment alone) and an observation group (45 cases, basic treatment combined with orthodontic treatment). PD, BI, tooth mobility (TM), and anterior tooth overjet-overbite relationship were compared between the two groups before treatment, 3 months after treatment, and 6 months after treatment. Results: After treatment, PD, BI, and TM in both groups were significantly reduced compared with pre-treatment (P<0.05). Moreover, PD (3.23±0.51) mm, BI (1.13±0.27), TM (0.91±0.16) at 3 months post-treatment, and PD (2.92±0.47) mm, BI (1.03±0.28), TM (0.82±0.17) at 6 months post-treatment in the observation group were significantly better than those in the control group (P<0.05). Additionally, the improvement of anterior tooth overjet (2.15±0.34) mm and overbite (1.25±0.28) mm at 6 months post-treatment in the observation group was superior to that in the control group (P<0.05). Conclusion: Periodontal basic treatment combined with orthodontic treatment can more effectively reduce PD and BI, improve tooth mobility and anterior tooth occlusal relationship in patients with periodontitis-induced anterior tooth displacement, with better efficacy than basic treatment alone.