Objective To explore the application of 2940 nm Er:YAG pixel laser combined with radiofrequency treatment in the repair of striae gravidarum. Methods A total of 48 female patients who received treatment for striae gravidarum in our hospital from June to December 2024 were selected and divided into the control group and the observation group by the random number table method, with 24 patients in each group. The control group was treated with conventional external application of asiaticoside ointment, and the observation group was treated with 2940 nm Er:YAG pixel laser combined with radiofrequency. The clinical efficacy and satisfaction were compared between the two groups. Results The total effective rate of treatment in the observation group was 87.50%, which was higher than 58.33% in the control group (P <0.05). The satisfaction in the observation group was 95.83%, which was better than 66.67% in the control group (P <0.05). Conclusion The 2940 nm Er:YAG pixel laser combined with radiofrequency has a better clinical effect in the treatment with striae gravidarum, and the patients have a higher satisfaction. It is worthy of clinical appication.