Objective To investigate the effect of orbicularis oculi myocutaneous flap combined with double eyelid blepharoplasty on flap survival rate and quality of life in patients with anterior lamella eyelid defect after eyelid lump resection. Methods A total of 80 patients with anterior lamella eyelid defect after eyelid lump resection who were admitted to the Department of Plastic Surgery, Wuxi AIST Plastic Surgery Hospital from January 2023 to December 2024 were selected as the research subjects, and they were divided into the control group and the observation group by the random number table method, with 40 patients in each group. The control group was treated with "kite" flap+double eyelid blepharoplasty, and the observation group was treated with orbicularis oculi myocutaneous flap+double eyelid blepharoplasty. The flap survival rate, clinical index, quality of life, satisfaction and complication rate were compared between the two groups. Results The flap survival rate of the two groups was 100.00%, and the difference was not statistically significant (P >0.05). The intraoperative blood loss and operation time of the observation group were better than those of the control group (P <0.05). The postoperative quality of life score of the observation group was higher than that of the control group (P <0.05). The treatment satisfaction rate of the observation group was 97.50%, which was higher than 80.00% of the control group (P <0.05). The incidence of complications of the observation group was 2.50%, which was lower than 15.00% of the control group (P <0.05). Conclusion Both orbicularis oculi myocutaneous flap and "kite" flap+double eyelid blepharoplasty can repair anterior lamella eyelid defect in patients after eyelid lump resection, and both have high flap survival rate. However, the orbicularis oculi myocutaneous flap+double eyelid plasty has the advantages of less complications, lower intraoperative blood loss, shorter operation time, and higher patient satisfaction and postoperative quality of life.