Objective To observe the effect of zirconia restoration on masticatory function in patients undergoing oral restoration. Methods A total of 60 patients who underwent oral restoration at Yinchuan Xingqing District Rui'er Clinic from March 2023 to February 2024 were selected as the research subjects. According to different restoration plans, they were divided into the control group and the observation group, with 30 patients in each group. The control group was restored with porcelain-fused-to-metal crown, and the observation group was restored with zirconia restoration. The masticatory function, restoration effect, and restoration satisfaction were compared between the two groups. Results After 1 week, 1 month and 3 months of restoration, the masticatory efficiency in the observation group was better than that in the control group, and the difference was statistically significant (P <0.05). The total effective rate of restoration in the observation group was 96.67%, which was higher than 80.00% in the control group, and the difference was statistically significant (P <0.05). The satisfaction scores of masticatory function, comfort, speech pronunciation and aesthetics in the observation group were all higher than those in the control group, and the differences were statistically significant (P <0.05). Conclusion The application of zirconia restoration in oral restoration can not only improve the masticatory function of patients, but also enhance the restoration effect, which is beneficial for improving patient satisfaction. The clinical application value is definite.