Striae distensae are atrophic stripes that commonly occur in tension areas throughout the body. They can seriously affect the appearance and cause great psychological distress to patients. There are many conventional methods for treating striae distensae clinically, such as laser photoelectric therapy and microneedle radiofrequency, but they have gradual effects and unsatisfactory treatment effects. In recent years, injection therapy has been increasingly used in the treatment of striae distensae and has gradually become a research hotspot. Injection therapies for striae distensae include the combination of low molecular hyaluronic acid and amino acids, platelet-rich plasma therapy, mesenchymal stem cell therapy and injection therapies with collagen stimulants such as poly-L-lactic acid and polycaprolactone. This paper reviews the research progress of injection therapy for striae distensae, aiming to analyze the efficacy and safety of injection therapy in improving striae distensae and explore the effect of combination therapy in enhancing the efficacy, so as to provide some reference value for the clinical treatment of striae distensae.