Objective: To analyze the application effect of negative pressure sealing drainage technology in the surgical nursing cooperation of burn wounds. Methods: According to the research content and inclusion exclusion criteria, 72 patients who meet the requirements and need to undergo burn wound surgery in our hospital were selected. They were admitted between January 2021 and June 2025 and divided into two groups with the same number of cases. Random number table method was used to divide them into two groups, with 36 cases in each group. The control group was treated with traditional dressing change and basic care, while the observation group was treated with negative pressure sealed drainage technology combined with systematic care. Compare the number of dressing changes, wound healing time, hospitalization time, postoperative pain improvement, and incidence of complications between the two groups. Results: Compared with the control group, the observation group showed a significant reduction in dressing changes and shorter wound healing and hospitalization time (P < 0.05). The pain scores of the observation group at 3 days, 5 days and 10 days after the operation were all lower than those of the control group (P < 0.05). The total incidence of complications in the observation group was lower than that in the control group (P < 0.05). Conclusion: The negative pressure closed drainage technique combined with systematic nursing is helpful to reduce the frequency of dressing changes for patients, shorten the wound healing time and hospital stay of patients, alleviate postoperative pain of patients, and lower the incidence of complications of patients.