Objective To investigate the effect of precision layered suture combined with chlortetracycline hydrochloride eye ointment on wound healing time and scar prevention in patients with facial soft tissue trauma. Methods A total of 80 patients with facial soft tissue trauma admitted to Guizhou Provincial People's Hospital from August 2022 to October 2024 were selected as the research subjects. According to different treatment plans, they were divided into the control group and the observation group, with 40 patients in each group. Both groups received precision layered suture. On this basis, the control group received conventional dressing change treatment, while the observation group received chlortetracycline hydrochloride eye ointment treatment. The wound healing time, scar prevention effect, complications and satisfaction were compared between the two groups. Results The wound healing time in the observation group was shorter than that in the control group (P <0.05). The total effective rate of scar prevention in the observation group was 90.00%, which was higher than 67.50% in the control group (P <0.05). The incidence of complications in the observation group was 2.50%, which was lower than 20.00% in the control group (P <0.05). The satisfaction rate in the observation group was 95.00%, which was higher than 65.00% in the control group (P <0.05). Conclusion Precision layered suture combined with chlortetracycline hydrochloride eye ointment has a good effect in the treatment of patients with facial soft tissue trauma, which can further shorten the wound healing time, improve the scar prevention effect, and has a low incidence of complications and high patient satisfaction. It is worthy of clinical application.