Objective To investigate the effect of subbrow incision for upper eyelid relaxation correction combined with microdroplet injection of type A botulinum toxin in the treatment of periorbital skin relaxation. Methods A total of 68 patients with periorbital skin relaxation admitted to our hospital from June 2023 to September 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the experimental group, with 34 patients in each group. The control group received subbrow incision for upper eyelid relaxation correction, and the experimental group received the combined treatment of subbrow incision for upper eyelid relaxation correction and microdroplet injection of type A botulinum toxin. The periorbital skin aging, periorbital wrinkle improvement, pain degree and complications were compared between the two groups. Results After treatment, the scores of skin roughness, sallow complexion, spot pigmentation and wrinkles in the experimental group were higher than those in the control group (P <0.05). After treatment, the scores of skin texture, tightness, pigmentation and overall improvement in the experimental group were higher than those in the control group (P <0.05). There was no significant difference in VAS scores between the two groups at 10 minutes and 30 minutes after treatment (P >0.05). The incidence of complications in the experimental group was 11.76%, which was higher than 5.88% in the control group, but the difference was not statistically significant (P >0.05). Conclusion Subbrow incision for upper eyelid relaxation correction combined with microdroplet injection of type A botulinum toxin can effectively improve periorbital skin relaxation and reduce periorbital wrinkles, without increasing pain or the incidence of complications.