Objective To analyze the effect of aesthetic restoration with digital oral photography combined with diagnostic model on marginal adaptation and color matching in patients with anterior teeth morphological proportion defect. Methods A total of 60 patients with anterior teeth morphological proportion defect admitted to the Clinic of Shanxi Vocational University of Engineering Science and Technology from August 2021 to August 2024 were selected as the research subjects. According to different repair treatment methods, they were divided into the control group (n =30) and the study group (n =30). The control group received conventional restoration, and the study group received aesthetic restoration with digital oral photography combined with diagnostic model. The marginal adaptation, color matching, aesthetic restoration score, gingival crevicular inflammatory factor indexes and patient satisfaction were compared between the two groups. Results The excellent and good rate of marginal adaptation in the study group (96.67%) was higher than that in the control group (73.33%) (P <0.05). The color matching rate in the study group (93.33%) was higher than that in the control group (73.33%) (P<0.05). The scores of gingival margin, comfort, color and aesthetics in the study group after treatment were all higher than those in the control group (P<0.05). The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the study group after treatment were lower than those in the control group (P<0.05). The patient satisfaction rate in the study group (93.33%) was higher than that in the control group (70.00%) (P <0.05). Conclusion Aesthetic restoration with digital oral photography combined with diagnostic model can effectively improve marginal adaptation, color matching and aesthetic restoration effect in patients with anterior teeth morphological proportion defect, and reduce gingival crevicular inflammatory response.