Objective To explore the improvement effect of intense pulsed light combined with CO2 fractional laser on early scar after facial cosmetic suture. Methods A total of 60 patients who underwent facial cosmetic suture in the Department of Dermatology, the Second Stationed Outpatient Department of General Hospital of Eastern Theater Command from January to July 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 30 patients in each group. The control group was intervened with facial suture+silicone gel application, and the observation group was intervened with intense pulsed light and CO2 fractional laser on the basis of the control group. The clinical efficacy, scar and pigmentation area, clinical symptom scores and adverse reaction rate were compared between the two groups. Results The total effective rate of the observation group was 96.67%, which was higher than 76.67% of the control group (P <0.05). The scar and pigmentation areas of the observation group were smaller than those of the control group (P <0.05). The ECCA score and acute inflammatory response semi-quantitative score of the observation group were lower than those of the control group (P <0.05). The incidence of adverse reactions in the observation group was 6.67%, which was lower than 26.67% in the control group (P <0.05). Conclusion In the prevention of early scar after facial cosmetic suture, the application of intense pulsed light combined with CO2 fractional laser can effectively improve the clinical efficacy of patients, reduce the incidence of adverse reactions, improve clinical symptoms, and effectively reduce the area of scar and pigmentation, which is worthy of clinical application.