Objective: To explore the effect of continuous closed negative pressure drainage technology combined with Recombinant bovine basic fibroblast growth factor (rb-bFGF) irrigation tube treatment on wound healing in patients with second-degree burns. Methods: A retrospective analysis was conducted on the clinical data of 92 patients with second-degree burns who were diagnosed and treated in Affiliated Hospital of Guilin Medical University from Septembe 2023 to September 2025. Forty-six patients treated with continuous closed negative pressure drainage technology were included in the control group, and 46 patients treated with continuous closed negative pressure drainage technology +rb-bFGF irrigation tube were included in the observation group. Compare the therapeutic effect, VAS score, wound healing and the occurrence of complications, and analyze the clinical value of the combined treatment plan. Result: Compared with the control group, the total effective rate of treatment in the observation group (95.65%>80.43%) was higher; The VAS and VASS scores were lower, and the average wound healing and complete scab dissolution time were shorter (P<0.05). The incidence of complications in the observation group was lower than that in the control group, but the difference between the two was not statistically significant (P>0.05). Conclusion: In the treatment of patients with second-degree burns, the combined application of continuous closed negative pressure drainage technology and rb-bFGF irrigation tube therapy can minimize the incidence of complications on the basis of promoting the improvement of uncomfortable symptoms such as pain and wound healing.