Objective: To study the effect of human epidermal growth factor gel combined with MEBO in the treatment of skin burns. Method: Fifty patients with skin burns and scalds treated in our hospital from June 2023 to June 2025 were randomly divided into a control group (25 cases) and treated with moist burn ointment; The observation group (25 cases) was treated with human epidermal growth factor gel combined with MEBO, and the therapeutic effects of the two groups were compared. Result: The observation group showed better wound repair efficacy, with shorter wound repair index time compared to the control group, and the difference was statistically significant (P<0.05); The Vancouver Scar Scale (VSS) score in the observation group decreased compared to the control group (P<0.05), and the concentration of growth factors that promote repair was upregulated in the observation group, while the level of inflammatory factors was downregulated (P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of human epidermal growth factor gel and MEBO has a synergistic effect in the treatment of burn and scald patients. By accelerating wound repair, promoting the expression of beneficial growth factors and inhibiting inflammatory reaction, the risk of scar formation is ultimately reduced, and the overall safety is controllable.