Objective: To investigate the efficacy and aesthetic outcomes of all-ceramic crown bridges combined with glass fiber posts in repairing large anterior tooth defects. Methods: Eighty-two patients with large anterior tooth defects treated in the hospital from January 2022 to December 2024 were selected and divided into groups based on different treatment protocols. The control group (n=41) received porcelain-fused-to-metal crown bridges with cast metal post cores, while the observation group (n=41) received all-ceramic crown bridges with glass fiber posts. Follow-up was conducted for 6 months to compare clinical efficacy, masticatory efficiency, evaluate periodontal and gingival crevicular fluid (GCF) indicators, and assess aesthetic outcomes. Results: After treatment, the observation group exhibited higher overall efficacy and masticatory efficiency (P<0.05); lower CAL, PD, and SBI (P<0.05); reduced levels of ICAM-1, MMP-2, and ALP in GCF (P<0.05); and higher red and white aesthetic scores (P<0.05). Conclusion: The combination of all-ceramic crown bridges and glass fiber posts demonstrates reliable efficacy in repairing large anterior tooth defects, minimizes adverse effects on periodontal tissues and GCF, and delivers excellent aesthetic results.