Objective: To investigate the effect of repairing wedge-shaped defects with flowing resin and glass ionomer cement. Method: 78 patients with wedge-shaped defects treated in hospitals from January 2022 to December 2024 were selected and grouped according to differences in repair materials. The control group (n=39) received glass ionomer cement repair, while the observation group (n=39) received flow resin repair. Compare the repair effect and success rate, degree of microleakage and aesthetic effect, gingival crevicular fluid inflammatory factors, and complications between two groups. Result: There was no significant difference in the repair effect and success rate between the two groups (P>0.05). The incidence of grade 0+I microleakage in the observation group was lower (P<0.05); The detection values of IL-1 β, IL-6, and TNF - α in the observation group were all lower (P<0.05); The white aesthetic score of the observation group was higher (P<0.05); There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: The effect and risk of complications of repairing wedge-shaped defects with flowing resin and glass ionomer cement are comparable, but the risk of micro leakage and inflammatory response with flowing resin is milder, and the aesthetic effect is better.