Objective To analyze the effect of low-pressure liposuction combined with radiofrequency laser and local fat grafting on the improvement of facial contour parameters in patients with mid-lower facial aging. Methods A total of 71 patients with midlower facial aging admitted to the Department of Plastic Surgery, Cangzhou Gaobo Natural Medical Aesthetic Clinic from March 2023 to September 2024 were selected as the research subjects. According to different treatment methods, they were divided into the control group (n =35) and the observation group (n =36). The control group was treated with facial low-pressure liposuction combined with radiofrequency laser, and the observation group was treated with local fat grafting on the basis of the control group. The facial contour parameters, overall aesthetic improvement and treatment satisfaction were compared between the two groups. Results There were no significant differences in lower facial width, lower facial length, middle facial length and chin angle between the two groups after treatment (P>0.05). The GAIS scores of self-evaluation and doctor evaluation in the observation group after treatment were lower than those in the control group (P<0.05). The treatment satisfaction rate of the observation group (100.00%) was higher than that of the control group (85.71%) (P<0.05) . Conclusion The treatment of facial low-pressure liposuction combined with radiofrequency laser and local fat grafting for mid-lower facial aging patients can actively improve the facial contour parameters of the middle and lower face, optimize facial overall aesthetic improvement effect, and improve treatment satisfaction.