Objective To analyze the effect of small incision liposuction combined with continuous embedding double eyelid plasty on surgical indicators in patients with asymmetric double eyelid. Methods A total of 60 patients with asymmetric double eyelid admitted to Urumqi Jin Pacific Medical Aesthetics Clinic from March 2023 to October 2024 were selected, and they were divided into the control group and the observation group by the random number table method, with 30 patients in each group. The control group was treated with conventional incision double eyelid plasty, and the observation group was treated with small incision liposuction combined with continuous embedding double eyelid plasty. The surgical indicators, satisfaction and complication rate were compared between the two groups. Results The operation time, intraoperative blood loss and incision healing time of the observation group were better than those of the control group (P <0.05). The satisfaction rate of the observation group was 93.33%, which was higher than 73.33% of the control group (P <0.05). The incidence of complications in the observation group was 3.33%, which was lower than 20.00% in the control group (P <0.05). Conclusion Small incision liposuction combined with continuous embedding double eyelid plasty for asymmetric double eyelid can effectively shorten the operation time and incision healing time, reduce intraoperative blood loss, lower the incidence of complications, and improve patient satisfaction, which is worthy of clinical application.