Objective To investigate the effect of hyaluronic acid sodium compound solution combined with facial embedding on skin status indicators in patients with tear trough and palpebromalar groove fine lines. Methods A total of 98 patients with tear trough and palpebromalar groove fine lines admitted to Changchun High-Tech Industrial Development Zone Xiafei Medical Beauty Clinic Co., Ltd. from August 2023 to August 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 49 patients in each group. The control group received facial embedding treatment, and the observation group received hyaluronic acid sodium compound solution combined with facial embedding treatment. The skin status indicators, clinical efficacy and complications were compared between the two groups. Results The wrinkle score of the observation group after treatment was (4.39±0.42)scores, which was lower than (4.68±0.56) scores of the control group (P <0.05). The texture score of the observation group after treatment was (5.52±0.43)scores, which was lower than (5.79±0.74)scores of the control group (P <0.05). The pore score of the observation group after treatment was (14.63±1.96)scores, which was lower than (15.72±2.04)scores of the control group (P <0.05). The total effective rate of treatment in the observation group was 95.92%, which was higher than 81.63% in the control group (P <0.05). The incidence of complications in the observation group was 6.12%, which was lower than 24.49% in the control group (P <0.05). Conclusion The treatment of hyaluronic acid sodium compound solution combined with facial embedding can effectively improve facial skin condition, reduce the incidence of complications, and improve clinical efficacy, which is worthy of clinical application.