Objective To analyze the effect of orthodontics combined with periodontal splint treatment on dental function and aesthetic effect in patients with anterior teeth displacement caused by periodontal disease. Methods A total of 56 patients with anterior teeth displacement caused by periodontal disease admitted to our hospital from January 2022 to December 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group (28 patients) and the combination group(28 patients). The control group was given simple periodontal splint treatment, and the combination group was given orthodontics combined with periodontal splint treatment. The tooth mobility, periodontal health indicators, serum inflammatory factor levels and satisfaction were compared between the two groups. Results The tooth mobility in the combination group after treatment was lower than that in the control group (P <0.05). The clinical attachment loss, percentage of bleeding on probing, and probing depth in the combination group after treatment were lower than those in the control group (P <0.05). The levels of CRP, TNF-α and IL-6 in the combination group after treatment were better than those in the control group (P <0.05). The satisfaction scores of aesthetics, comfort and function in the combination group were higher than those in the control group (P <0.05). Conclusion For patients with anterior teeth displacement caused by periodontal disease, the application of orthodontics combined with periodontal splint treatment has a positive impact on improving dental function and aesthetics, which can effectively reduce periodontal inflammatory response, accelerate periodontal tissue repair, and increase tooth stability.