Objective To investigate the effect of immediate loading implantation after edentulous implantation guided by digital guide on implant accuracy in edentulous restoration patients. Methods A total of 64 patients who underwent edentulous restoration in Xiangtan Stomatological Hospital from January 2023 to August 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 32 patients in each group. The control group was given traditional edentulous implantation, and the observation group was given immediate loading implantation after edentulous implantation guided by digital guide. The implant accuracy, repair effect and complications were compared between the two groups. Results The deviations of neck, root, depth and angle in the observation group were smaller than those in the control group (P <0.05). The total effective rate of restoration in the observation group (96.88%) was higher than that in the control group (84.38%), but the difference was not statistically significant(P >0.05). The incidence of complications in the observation group (6.25%) was lower than that in the control group (28.13%) (P <0.05). Conclusion Compared with traditional edentulous implantation, immediate loading implantation after edentulous implantation guided by digital guide has higher implant accuracy and lower incidence of complications after restoration, which is worthy of clinical application.