Objective To compare and analyze the efficacy of moist exposed burn ointment and sulfadiazine silver cream in wound repair of patients with second-degree burn. Methods A total of 52 patients with second-degree burn admitted to our hospital from May 2023 to February 2025 were selected and divided into the control group (n =26) and the experimental group (n =26) by random number table method. The control group was treated with sulfadiazine silver cream, and the experimental group was treated with moist exposed burn ointment. The clinical efficacy, wound healing time pigmentation regression time, wound healing rate, scar hyperplasia degree, pain degree, serum inflammatory factor levels and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the experimental group was 100.00%, which was higher than 76.92% in the control group (P <0.05). The wound healing time and pigmentation regression time of the experimental group were shorter than those of the control group, and the wound healing rate was higher than that of the control group (P <0.05). The VSS and VAS scores of the experimental group after treatment were lower than those of the control group (P <0.05). The levels of serum IL-8, CRP and TNF-α in the experimental group after treatment were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion Moist exposed burn ointment has better efficacy than sulfadiazine silver cream in wound repair of patients with second-degree burn, which can shorten wound healing time and pigmentation regression time, increase wound healing rate, reduce wound scar hyperplasia and pain degree, and lower inflammatory factor levels.