Objective To explore the clinical efficacy of biofunctional complete denture restoration in the treatment of patients with edentulous jaw. Methods A total of 80 patients with edentulous jaw admitted to Hanzhong Stomatological Hospital from January 2020 to February 2023 were selected, and they were divided into the traditional restoration group and the biodenture group according to different treatment methods, with 40 patients in each group. The traditional restoration group received traditional restoration, and the bio-denture group received biofunctional complete denture restoration. The clinical efficacy, dental conditions (alveolar ridge height, masticatory efficiency, absorbance value of masticated food), clinical indicators (quality of life score, comfort score and satisfaction score) were compared between the two groups. Results The total effective rate of the bio-denture group (95.00%) was highe r than that of the traditional restoration group (77.50%) (P <0.05). After treatment, the alveolar ridge height, masticatory efficiency and absorbance value of masticated food in the bio-denture group were higher than those in the traditional restoration group (P <0.05). The quality of life score, comfort score and satisfaction score in the bio-denture group were higher than those in the traditional restoration group (P <0.05). Conclusion Biofunctional complete denture restoration has a good effect in patients with edentulous jaw, which can improve their dental conditions, and enhance their quality of life, comfort and satisfaction.