Objective To investigate the effect of concentrated growth factor (CGF) combined with periodontal guided bone regeneration (GBR) on implant retention rate and implant stability in transcrestal sinus floor elevation with simultaneous dental implantation. Methods A total of 17 patients who underwent transcrestal sinus floor ele vation with simultaneous dental implantation for narrow alveolar ridge implantation of posterior teeth at No.9 People's Hospital of Nanning from January 2024 to January 2025 were selected as the research subjects. According to different treatment methods, they were divided into the control group (n =8) and the observation group (n =9). The control group was treated with GBR, and the observation group was treated with CGF combined with GBR. The implant retention rate, implant stability and bone mineral density were compared between the two groups. Results The implant retention rate of the observation group (100.00%) was higher than that of the control group (62.50%) (P <0.05). The implant torque value, implant stability quotient and bone mineral density in the observation group after treatment were better than those in the control group (P <0.05). Conclusion The application of CGF combined with GBR in transcrestal sinus floor elevation with simultaneous dental implantation has a good effect, which can effectively improve the implant retention rate, improve bone mineral density, and optimize the implant stability quotient. It is worthy of clinical application.