Objective To explore the effect of recombinant human epidermal growth factor gel (rhEGF) combined with aesthetic debridement and suture on wound healing time in patients with maxillofacial trauma. Methods A total of 100 patients who underwent tension free suture for maxillofacial trauma in Zijin County People's Hospital from January 2024 to January 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 50 patients in each group. The control group received aesthetic debridement and suture, and the observation group received rhEGF combined with aesthetic debridement and suture. The treatment effect, wound healing time, serum recombinant human epidermal growth factor (serum EGF) level and adverse reaction rate were compared between the two groups. Results The total effective rate of treatment in the observation group (98.00%) was higher than that in the control group (84.00%) (P <0.05). The wound incrustation time and wound healing time in the observation group were shorter than those in the control group (P <0.05). The serum EGF level in the two groups after intervention was higher than that before intervention, and that in the observation group was higher than that in the control group (P <0.05). The incidence of adverse reactions in the observation group (2.00%) was lower than that in the control group (16.00%) (P <0.05). Conclusion The application of rhEGF combined with aesthetic debridement and suture can improve the effect of tension free suture for maxillofacial trauma, increase serum EGF level, promote rapid wound healing, and reduce the incidence of adverse reactions, which is worthy of clinical application.