Objective To analyze the effect of concentrated growth factor (CGF) combined with orthodontic treatment on bone resorption and aesthetic effect in patients with periodontitis. Methods A total of 80 patients with periodontitis admitted to Nanchang Jiangwei Dental Clinic from April 2021 to June 2022 were selected as the research subjects, and they were divided into the reference group and the intervention group by the random number table method, with 40 patients in each group. The reference group was given orthodontic treatment, and the intervention group was given CGF combined with orthodontic treatment. The marginal bone resorption marker concentrations, inflammatory factor levels, modified Sulcus Bleeding Index (mSBI), modified Plaque Index (mPLI) and smile aesthetics indicators were compared between the two groups. Results The level of RANKL in the intervention group was lower than that in the reference group, and the levels of OPG and Wnt3a were higher than those in the reference group (P <0.05). The levels of E-selectin, ICAM-1 and HMGB1 in the intervention group were lower than those in the reference group (P <0.05). The scores of mSBI and mPLI the intervention group at 3 and 6 months after treatment were lower than those in the reference group (P <0.05). The smile curve and gingival exposure of the intervention group at 6 months after treatment were less than those in the reference group (P <0.05). Conclusion CGF combined with orthodontic treatment has a good effect in patients with periodontitis. It can effectively reduce marginal bone resorption marker concentrations and inflammatory factor levels,alleviate gingival bleeding and plaque accumulation, improve dental aesthetics and promote periodontal health.