Objective To explore the effect of Traditional Chinese Medicine (TCM) characteristic nursing on skin repair in acne patients. Methods A total of 100 acne patients admitted to our hospital from April 2023 to April 2024 were selected as the research subjects, and they were divided into the control group and the observation group by the random number table method, with 50 patients in each group. The control group received conventional skin nursing, and the observation group received TCM characteristic nursing on the basis of the control group. The skin lesion improvement, sebum secretion, inflammatory factor levels and nursing satisfaction were compared between the two groups. Results The total effective rate of skin lesion improvement in the observation group (92.00%) was higher than that in the control group (76.00%) (P <0.05). After nursing, the proportion of grade Ⅰ sebum secretion in the observation group was higher than that in the control group, the proportion of grade Ⅲ was lower than that in the control group, and the serum levels of IL-6 and TNF-α were lower than those in the control group (P <0.05). The nursing satisfaction in the observation group (96.00%) was higher than that in the control group (84.00%) (P <0.05). Conclusion TCM characteristic nursing can effectively promote skin repair in acne patients, improve clinical symptoms, inhibit skin inflammatory response, and enhance nursing satisfaction.