Objective To analyze the effect of double dentition restoration on oral and maxillofacial improvement effect in patients with cleft lip and palate. Methods A total of 110 patients with cleft lip and palate admitted to the Department of Stomatology, Affiliated Hospital of North Sichuan Medical College from June 2022 to June 2024 were selected as the research subjects, and they were grouped by the red-blue ball drawing method: 55 patients who drew red balls formed the control group and received conventional fixed bridge restoration, whereas 55 patients who drew blue balls formed the observation group and received double dentition restoration. The treatment effect, oral restoration indicators, oral and maxillofacial improvement effect and restoration satisfaction were compared between the two groups. Results The total effective rate of treatment in the observation group (96.36%) was higher than that in the control group (76.36%) (P<0.05). The scores of dentition integrity, masticatory function, facial aesthetics and pronunciation in the observation group were higher than those in the control group (P <0.05). The ANB angle, SNB angle and SNA angle in the observation group after treatment were better than those in the control group (P <0.05). The restoration satisfaction of the observation group (94.55%) was higher than that of the control group (72.73%) (P <0.05). Conclusion The effect of double dentition restoration in the treatment of cleft lip and palate repair is good. This technology can not only effectively improve patients' oral and maxillofacial structure, restore dentition integrity and masticatory function, but also enhance patients' facial aesthetics and pronunciation clarity, with high patient satisfaction.