Objective To observe the effect of four-handed nursing on masticatory function and dental aesthetics in patients with minimally invasive aesthetic restoration of anterior teeth. Methods A total of 60 patients with minimally invasive aesthetic restoration of anterior teeth admitted to our hospital from January 2024 to January 2025 were divided into the control group and the experimental group by the random number table method, with 30 patients in each group. The control group received conventional nursing, and the experimental group received four-handed nursing. The masticatory function, dental aesthetics, dental health index, nursing satisfaction and adverse reaction rate were compared between the two groups. Results After nursing, the masticatory function, anterior tooth occlusion, implant color, gingival condition, alveolar bone condition, soft tissue color and total aesthetics score in the experimental group were better than those in the control group (P <0.05). The GI and SBI in the experimental group after nursing were lower than those in the control group (P <0.05). The incidence of adverse reactions in the experimental group (3.33%) was lower than that in the control group (23.33%), and the nursing satisfaction (100.00%) was higher than that in the control group (86.67%) (P <0.05). Conclusion The application of four-handed nursing in patients with minimally invasive aesthetic restoration of anterior teeth is beneficial to improving masticatory function, dental aesthetics, dental health index and nursing satisfaction, and has high safety.